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Novel
Herbal Therapy for Men at High Risk of
Prostate Cancer - Phase 1 Results
Newswise — Results of a phase I clinical
trial of a novel herb-based therapeutic
called Zyflamend have demonstrated that the
therapy is associated with minimal toxicity
and no serious adverse events in men at
high-risk for developing prostate cancer.
The new findings, led by researchers from
the Center for Holistic Urology at Columbia
University Medical Center and NewYork-Presbyterian
Hospital/Columbia, are published in the
current issue of the Journal of the Society
for Integrative Oncology.
In the study, 23 men ages 40-75 years-old
who were diagnosed with high-grade prostatic
intraepithelial neoplasia (HGPIN) at biopsy,
lesions that indicate an increased risk of
developing prostate cancer, were admitted
into this prospective clinical trial, in
order to determine the safety and
tolerability of Zyflamend when administered
orally for 18-months, either alone or along
with various dietary supplements.
“Since we know that men with HGPIN have an
increased risk for developing prostate
cancer, new strategies formulated to
decrease cancer risk, prevent or delay
surgery, and improve quality of life, will
be greatly beneficial for these men,” said
Aaron E. Katz, M.D., senior author of the
study.
He is associate professor of urology at
Columbia University College of Physicians
and Surgeons, director of the Center of
Holistic Urology at Columbia University
Medical Center and a urologist at NewYork-Presbyterian/Columbia.
Basic science studies have indicated that
Zyflamend may have an anti-inflammatory
mechanism of action and the agent has been
shown to decrease prostate cancer
proliferation in cell culture.
“Our results confirm that Zyflamend, in a
dose of three times daily for up to
18-months, was well tolerated,” said Jillian
L. Capodice, M.S., director of the
Acupuncture Research and Integrative
Clinical Service of the Department of
Urology’s Center for Holistic Urology, at
Columbia University College of Physicians
and Surgeons.
Prostate cancer is a cancer that forms in
tissues of the prostate (a gland in the male
reproductive system found below the bladder
and in front of the rectum).
Prostate cancer usually occurs in older men.
The National Cancer Institute estimates that
in 2009 there will be 192,280 new cases of
prostate cancer diagnosed and 27,360 deaths
attributed to prostate cancer in the United
States.
NewYork-Presbyterian Hospital, based in New
York City, is the nation’s largest
not-for-profit, non-sectarian hospital, with
2,242 beds.
The Hospital has nearly 2 million inpatient
and outpatient visits in a year, including
more than 230,000 visits to its emergency
departments — more than any other area
hospital. NewYork-Presbyterian provides
state-of-the-art inpatient, ambulatory and
preventive care in all areas of medicine at
five major centers: NewYork-Presbyterian
Hospital/Weill Cornell Medical Center,
NewYork-Presbyterian Hospital/Columbia
University Medical Center, NewYork-Presbyterian
Morgan Stanley Children’s Hospital, NewYork-Presbyterian
Hospital/The Allen Pavilion and NewYork-Presbyterian
Hospital/Westchester Division.
One of the largest and most comprehensive
health care institutions in the world, the
Hospital is committed to excellence in
patient care, research, education and
community service. NewYork-Presbyterian is
the #1 hospital in the New York metropolitan
area and is consistently ranked among the
best academic medical institutions in the
nation, according to U.S.News & World
Report.
The Hospital has academic affiliations with
two of the nation’s leading medical
colleges: Weill Cornell Medical College and
Columbia University College of Physicians
and Surgeons. For more information, visit
www.nyp.org.
Columbia University Medical Center provides
international leadership in basic,
pre-clinical and clinical research, in
medical and health sciences education, and
in patient care. The medical center trains
future leaders and includes the dedicated
work of many physicians, scientists, public
health professionals, dentists, and nurses
at the College of Physicians & Surgeons, the
Mailman School of Public Health, the College
of Dental Medicine, the School of Nursing,
the biomedical departments of the Graduate
School of Arts and Sciences, and allied
research centers and institutions.
Established in 1767, Columbia’s College of
Physicians & Surgeons was the first
institution in the country to grant the M.D.
degree. Among the most selective medical
schools in the country, the school is home
to the largest medical research enterprise
in New York State and one of the largest in
the country. For more information, visit
www.cumc.columbia.edu.
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