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Vitamin E, Selenium and Soy in combination
does not prevent Prostate Cancer
Newswise — The combination therapy of vitamin E, selenium
and soy does not prevent the progression
from high-grade prostatic intraepithelial
neoplasia (HGPIN) to prostate cancer,
according to the new research presented at
the 104th Annual Scientific Meeting of the
American Urological Association (AUA).
The study confirms the findings of the Selenium and Vitamin
E Cancer Prevention Trial (SELECT) and
expands knowledge of the affect soy has on
prostate cancer.
Canadian researchers divided 303 men, with an average age
of 62, into two randomized groups.
All participants had HGPIN, a precursor to invasive
prostate cancer, as confirmed by a central
pathology review in at least one of two
biopsies within 18 months prior to
randomization.
The combination treatment was administered daily for three
years with follow-up prostate biopsies at
six, 12, 24 and 36 months.
Supplementation was discontinued if a man developed
invasive disease.
Study results show that 26.4 percent of patients developed
invasive prostate cancer.
Baseline, age, weight and testosterone levels did not
predict the development of cancer.
“Unfortunately, as this study shows, we have yet to find a
dietary supplement that will reliably
prevent prostate cancer.
The results of this study support the findings of the
SELECT trial which also demonstrated no
benefit using Vitamin E and selenium,” said
Christopher Amling, MD, an AUA spokesman.
“These studies highlight the importance of conducting
randomized trials of these agents since many
of these supplements are promoted falsely to
the general public as having beneficial
effects on cancer prevention and
progression.”
About the American Urological
Association
Founded in 1902 and headquartered near
Baltimore, Maryland, the American Urological
Association is the pre-eminent professional
organization for urologists, with more than
16,000 members throughout the world.
An educational nonprofit organization, the AUA pursues its
mission of fostering the highest standards
of urologic care by carrying out a wide
variety of programs for members and their
patients.
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