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American College of Rheumatology Research
and Education Foundation awards new research
grants for Rheumatoid Arthritis Research
Newswise — The American College of
Rheumatology Research and Education
Foundation (ACR REF) has selected 15
experienced researchers from leading
institutions to receive an estimated $6
million from the Foundation’s Within Our
Reach: Finding a Cure for Rheumatoid
Arthritis campaign.
The awards are the
second round of grants funded by the $30
million national multi-year fundraising
effort focused specifically on rheumatoid
arthritis.
The American College of Rheumatology
Research and Education Foundation launched
the Within Our Reach: Finding a Cure for
Rheumatoid Arthritis campaign in November
2006 to accelerate RA research and expand
financial support for this disease which
affects an estimated 1.3 million Americans.
The program is designed to raise funds for
RA research so that, with the guidance of
ACR Research and Education Foundation,
Within Our Reach will continue to pioneer
advances in RA research.
"There have been great strides made in the
treatment and management of RA and it is
crucial that we continue to financially
support RA research,” said Dr. Leslie J.
Crofford, President of the REF.
"We are confident that the new grantees are
among the brightest and most promising
researchers in their field and will play a
critical role in moving us closer to a
cure."
As one of the largest funders of
rheumatology research and training programs
in the U.S, the ACR Research and Education
Foundation received numerous grant
applications from the nation’s most
outstanding and distinguished researchers.
The Within Our Reach campaign has built a
reputation for supporting research not done
elsewhere and after an extensive peer review
process, the REF is continuing this
tradition by selecting the most promising
proposals with new and unprecedented
approaches to RA research. Grant recipients
include:
Innovative Basic Research
Paul Ryan Thompson, PhD
University of South Carolina
Inhibition of PAD Function as a Novel
Treatment Strategy for Rheumatoid Arthritis
Gregg J. Silverman, MD
The University of California, San Diego
Natural Antibody Treatment of Inflammatory
Arthritis
Ellen M.Gravallese, MD
University of Massachusetts Medical School
Role of sFRP1 and WNT Signaling in Formation
and Repair of Erosions in RA
Michael B. Brenner, MD
Brigham and Women's Hospital
How FLS Mediate Cadherin-11 Dependent
Inflammation in RA
Xu Feng, PhD
University
of Alabama at Birmingham
In vivo Validation of Novel Therapeutic
Targets for Arthritic Bone Erosion
Song Guo Zheng, MD
Keck School of Medicine at the University of Southern
California
Generation of Collagen-specific
CD4+Foxp3+regulatory T cells Ex-vivoas an
Adoptive Immunotherapy for Rheumatoid
Arthritis
Richard M. Pope, MD
Northwestern University Feinberg School of
Medicine
Endogenous Toll-like Receptor Ligands in
Rheumatoid Arthritis
Shiva Shahrara, PhD
Northwestern University Feinberg School of
Medicine
The Role of IL-17 in the Pathogenesis of
Rheumatoid Arthritis
Steven Reyburn Goldring, MD
Hospital for Special Surgery
Bone Matrix-Induced Osteoclast Genes:
Identification of Novel Targets for RA
Translational Research
Larry W. Moreland, MD
University of Pittsburgh
Multi-cytokine Profiling and Correlates with
Outcome Measures and Treatment Responses in
Patients with Early Rheumatoid Arthritis
Peter K. Gregersen, MD
Feinstein Institute for Medical Research
Cross Racial Strategies for Gene
Identification in Rheumatoid Arthritis
William F. C. Rigby, MD
Dartmouth College
CD154 CA Repeat Polymorphisms and RA
Pathogenesis
Carl Grunfeld, MD, PhD
University
of California, San Francisco
Novel Cardiovascular Disease Risk Factors in
Patients with Rheumatoid Arthritis
Robert M. Plenge, MD, PhD
Brigham and Women's Hospital
Genome-wide Association Study of Response to
Anti-TNF Therapy in Rheumatoid Arthritis
Clinical Practice
Kenneth G. Saag, MD, MSc
University
of Alabama at Birmingham
Improving Bone Health Among RA Patients on
Chronic Glucocorticoids
About Within Our Reach: Finding a Cure for
Rheumatoid Arthritis
Rheumatoid arthritis affects an estimated
1.3 million Americans, yet funding to find
new treatments and ultimately a cure remains
significantly low compared to other
autoimmune diseases.
To address the critical need for additional
funding and research support, the REF
launched Within Our Reach in November 2006.
Within Our Reach is the largest private
fundraising campaign in the REF’s history.
It will tap a diverse donor base, and funds
raised will support innovative research to
learn more about the causes of RA and,
ultimately, to find a cure.
Since November 2006, the campaign has
received tremendous support from the
pharmaceutical industry, biotech companies,
physicians and patients, raising more than
$18 million.
Specific research areas for Within Our Reach
include:
• Innovative Basic Research: Research in
this area will help us understand what
causes RA and develop novel treatments.
• Translational Research: Translational
research is the direct study of patients and
patient-derived materials to improve the
understanding of RA. Research in this area
will study the joint and its cells and
tissues to develop methods to repair and
replace damaged cartilage and bone.
• Clinical Practice: This area explores the
issues that directly affect the clinical
practice of rheumatology and patient access.
This research can possibly lead to the
development of methods to identify
individuals at risk for RA to facilitate
prevention and early treatment.
• Novel Clinical Trials: Novel clinical
trials will address the unmet needs in the
development of new treatments for patients
who may be resistant to conventional
treatments or biologics.
• Collaborative Projects: Collaborative
projects are large-scale collaborative
research groups where expertise from
multiple sites and investigators are joined
together to solve one problem with
comprehensive and innovative approaches.
“No other organization is better equipped to
help meet the demand for better patient care
today while advancing the course of research
that will yield tomorrow’s medical
breakthroughs,” added Dr. Crofford.
“We are confident the research Within Our
Reach yields will enhance rheumatologists’
ability to diagnose and treat patients
suffering from this painful and potentially
debilitating disease.”
To learn more about rheumatoid arthritis and
the campaign, please visit
http://www.WithinOurReach.info .
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