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External-Beam Radiation therapy for
localized Prostate Cancer linked to Bladder,
Lung and Colorectal Cancer
Newswise — Patients undergoing external-beam
radiation therapy (EBRT) for localized
prostate cancer may be at an increased risk
for secondary malignancy, according to a
study from researchers in Canada, Italy and
the United States presented during the
Annual Scientific Meeting of the American
Urological Association (AUA) in Orlando.
These findings have significant implications
for men evaluating treatment options for
localized prostate cancer.
Using records from 10,333 men treated for
localized prostate cancer (6,196 with
radical prostatectomy and 4,137 with EBRT)
between 1983 and 2004, researchers examined
subsequent diagnoses of bladder, lung and
colorectal cancer to determine whether the
incidence rate of these secondary
malignancies was greater in patients who
underwent EBRT as opposed to radical
prostatectomy.
Researchers used diagnosis codes defining
cystectomy, lobectomy or pneumectomy (for
lung cancer) and colectomy (with or without
rectal resection) for colorectal cancer to
identify the incidence of secondary
malignancy in this study population. 92
cystectomies, 82 lung cancer surgeries and
228 colorectal cancer surgeries were
performed.
Univariable analyses showed an increase in
the rate of secondary malignancy treatment
in men treated with EBRT.
Multivariate analysis was performed, with
adjustments made for age, baseline
comorbidities and year of treatment – and
indicated that EBRT predisposed patients to
a 3.0-fold increase for cystectomy for
bladder cancer, 1.8-fold rate of lung-cancer
resections and 1.7-fold higher rate of
rectal cancer.
About the American Urological Association
Founded in 1902 and headquartered near
Baltimore, Maryland, the American Urological
Association is the pre-eminent professional
organization for urologists, with more than
15,000 members throughout the world.
An educational nonprofit organization, the
AUA pursues its mission of fostering the
highest standards of urologic care by
carrying out a wide variety of programs
members and their patients, including
UrologyHealth.org, an award-winning on-line
patient education resource, and the American
Urological Association Foundation, Inc.
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