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Men Treated for Localized Prostate Cancer
Could Benefit from Pomegranate Juice
Consumption
Newswise — Pomegranate juice may slow the progression of
post-treatment prostate cancer recurrence,
according to new long-term research results
being presented at the 104th Annual
Scientific Meeting of the American
Urological Association (AUA).
Researchers found that men who have undergone treatment for
localized prostate cancer could benefit from
drinking pomegranate juice.
The two-stage clinical trial followed a total of 48
participants over six years.
Eligible participants had a rising PSA after surgery or
radiotherapy, a PSA greater than 0.2 ng/ml
and less than 5 ng/ml and a Gleason score of
7 or less.
These patients were treated by drinking eight ounces of
pomegranate juice daily.
Currently, in the sixth year of treatment, active patients
who remain on the study have a median total
follow-up of 56 months.
These participants continue to experience a significant
increase in PSA doubling time following
treatment, from a mean of 15.4 months at
baseline to 60 months post-treatment, with a
median PSA slope decrease of 60 percent,
0.06 to 0.024.
Researchers compared active patients, who remain on the
study, with non-active patients, who no
longer remain on the study.
Though these two groups demonstrated similar mean PSA
doubling times at baseline, both the PSA
doubling time prolongation and the decline
in median PSA slope were greater in active
patients when compared to non-active
patients.
“This study suggests that pomegranate juice may effectively
slow the progression of prostate cancer
after unsuccessful treatment,” said
Christopher Amling, MD, an AUA spokesman.
“This finding and other ongoing research might one day
reveal that pomegranate juice is an
effective prostate cancer preventative agent
as well.”
Parts of this ongoing study suggest that some patients may
be more sensitive to the effects of
pomegranate juice on PSA doubling time.
Phase three of this study is currently underway to further
evaluate the benefits of pomegranate juice
in a placebo-controlled manner.
About the American Urological Association:
Founded in 1902 and headquartered near Baltimore, Maryland,
the American Urological Association is the
pre-eminent professional organization for
urologists, with more than 16,000 members
throughout the world.
An educational nonprofit organization, the AUA pursues its
mission of fostering the highest standards
of urologic care by carrying out a wide
variety of programs for members and their
patients.
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