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Widespread Vitamin and
Mineral use among Cancer Survivors, although
benefits remain unclear
Newswise — Use of vitamin and mineral
supplements among cancer survivors is
widespread, despite inconclusive evidence
that such use is beneficial, according to a
comprehensive review of scientific
literature conducted by researchers at Fred
Hutchinson Cancer Research Center and
published Feb. 1 in the Journal of Clinical
Oncology.
“Can vitamin and herbal supplements reduce
the adverse effects of cancer treatment,
decrease the risk of cancer recurrence or
improve a patient’s chances of survival? We
don’t really know. Research into these
matters has been minimal,” said senior
author Cornelia (Neli) Ulrich, Ph.D., an
associate member of the Hutchinson Center’s
Public Health Sciences Division.
“While supplement use may be beneficial for
some patients, such as those who cannot eat
a balanced diet, research suggests that
certain supplements may actually interfere
with treatment or even accelerate cancer
growth,” she said.
In reviewing 32 studies conducted between
1999 and 2006, Ulrich and co-author
Christine Velicer, Ph.D., formerly a
postdoctoral fellow at the Hutchinson Center
(now an epidemiologist at Merck Research
Laboratory in North Wales, Pa.), found that
many of the nation’s 10 million adult cancer
survivors use nutritional supplements.
They found 64 percent to 81 percent of
cancer survivors overall reported using
vitamins or minerals (excluding
multivitamins), whereas in the general
population only 50 percent of adults
reported taking dietary supplements.
Survivors of breast cancer reported the
highest use (75 percent to 87 percent),
whereas prostate-cancer survivors reported
the least (26 percent to 35 percent).
Factors associated with the highest level of
supplement use overall included a higher
level of education and being female.
The researchers also found that many people
initiate the use of vitamins and supplements
after cancer diagnosis; between 14 percent
and 32 percent start taking them after
learning they have cancer.
“Cancer survivors report that they hope to
strengthen their immune system with
supplement use or gain a sense of control
and empowerment,” Ulrich said.
However, many cancer survivors who use
supplements do not let their doctors know;
31 percent to 68 percent of cancer patients
and survivors who use supplements may not
disclose this information or their doctors
may fail to record it in their charts.
“This is disconcerting and suggests that
many physicians may not recognize the
importance of understanding whether their
patients are taking supplements,” Ulrich
said.
Knowing about supplement use is crucial, she
continues, because of potential adverse
effects. “Evidence clearly suggests the need
for caution,” Ulrich said.
“Some vitamins, such as folic acid, may be
involved in cancer progression while others,
such as St. John’s wort, can interfere with
chemotherapy. However, we really need more
research to understand whether use of these
supplements can be beneficial or do more
harm than good.”
Until research clarifies the effects of
vitamin use in cancer survivors, the authors
urge health care professionals to
communicate openly with their patients about
supplement use.
“A simple explanation that medical studies
show supplement use may not always be
beneficial may help cancer survivors make
well-informed decisions,” the authors wrote.
The National Cancer Institute funded this
research.
At Fred Hutchinson Cancer Research Center,
our interdisciplinary teams of
world-renowned scientists and humanitarians
work together to prevent, diagnose and treat
cancer, HIV/AIDS and other diseases.
Our
researchers, including three Nobel
laureates, bring a relentless pursuit and
passion for health, knowledge and hope to
their work and to the world. For more
information, please visit fhcrc.org.
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